Lineage for d1boza_ (1boz A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137112Domain d1boza_: 1boz A: [34905]
    complexed with ndp, prd

Details for d1boza_

PDB Entry: 1boz (more details), 2.1 Å

PDB Description: structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductase and potential antitumor agents
PDB Compounds: (A:) protein (dihydrofolate reductase)

SCOPe Domain Sequences for d1boza_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1boza_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1boza_:

Click to download the PDB-style file with coordinates for d1boza_.
(The format of our PDB-style files is described here.)

Timeline for d1boza_: