SCOPe 2.08: Domain d5xu8a_: 5xu8 A:

Lineage for d5xu8a_ (5xu8 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 2, USP2 [159841] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159842] (5 PDB entries)
   Uniprot O75604 263-600! Uniprot O75604 264-599

8. Domain d5xu8a_: 5xu8 A: [348692]
   Other proteins in same PDB: d5xu8b_
   automated match to d3nhea_
   complexed with cl, dx4, na, zn

Details for d5xu8a_

PDB Entry: 5xu8, 1.81 Å

PDB Description: crystal structure of human usp2 in complex with ubiquitin and 6- thioguanine

PDB Compounds: (A:) Ubiquitin carboxyl-terminal hydrolase 2

SCOPe Domain Sequences for d5xu8a_:

Sequence, based on SEQRES records:

>d5xu8a_ d.3.1.9 (A:) Ubiquitin carboxyl-terminal hydrolase 2, USP2 {Human (Homo sapiens) [TaxId: 9606]}
qglaglrnlgntcfmnsilqclsntrelrdyclqrlymrdlhhgsnahtalveefakliq
tiwtsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvtlrpksn
penldhlpddekgrqmwrkyleredsrigdlfvgqlkssltctdcgycstvfdpfwdlsl
piakrgypevtlmdcmrlftkedvldgdekptccrcrgrkrcikkfsiqrfpkilvlhlk
rfsesrirtsklttfvnfplrdldlrefasentnhavynlyavsnhsgttmgghytaycr
spgtgewhtfndssvtpmsssqvrtsdayllfyela

Sequence, based on observed residues (ATOM records):

>d5xu8a_ d.3.1.9 (A:) Ubiquitin carboxyl-terminal hydrolase 2, USP2 {Human (Homo sapiens) [TaxId: 9606]}
qglaglrnlgntcfmnsilqclsntrelrdyclqrlymrdlhhgsnahtalveefakliq
tiwtsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvnldhlpd
dekgrqmwrkyleredsrigdlfvgqlkssltctdcgycstvfdpfwdlslpiakrgype
vtlmdcmrlftkedvldgdekptccrcrgrkrcikkfsiqrfpkilvlhlkrfsesrirt
sklttfvnfplrdldlrefasentnhavynlyavsnhsgttmgghytaycrspgtgewht
fndssvtpmsssqvrtsdayllfyela

Timeline for d5xu8a_:

• d5xu8a_ first appeared in SCOPe 2.07