SCOPe 2.08: Domain d5w8ka1: 5w8k A:1-159

Lineage for d5w8ka1 (5w8k A:1-159)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.5: LDH N-terminal domain-like [51848] (9 proteins)

6. Protein Lactate dehydrogenase [51859] (19 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (39 PDB entries)

8. Domain d5w8ka1: 5w8k A:1-159 [347990]
   Other proteins in same PDB: d5w8ka2, d5w8kb2, d5w8kc2, d5w8kd2
   automated match to d4jnka1
   complexed with 9y7, gol, mla, nai

Details for d5w8ka1

PDB Entry: 5w8k, 1.6 Å

PDB Description: crystal structure of lactate dehydrogenase a in complex with inhibitor compound 29 and nadh

PDB Compounds: (A:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d5w8ka1:

Sequence, based on SEQRES records:

>d5w8ka1 c.2.1.5 (A:1-159) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvig

Sequence, based on observed residues (ATOM records):

>d5w8ka1 c.2.1.5 (A:1-159) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
atlkdqliynllkeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkgem
mdlqhgslflrtpkivsgkdynvtansklviitagarlnlvqrnvnifkfiipnvvkysp
nckllivsnpvdiltyvawkisgfpknrvig

Timeline for d5w8ka1:

• d5w8ka1 first appeared in SCOPe 2.07