Lineage for d5vp1b2 (5vp1 B:575-577)

  1. Root: SCOPe 2.07
  2. 2598798Class l: Artifacts [310555] (1 fold)
  3. 2598799Fold l.1: Tags [310573] (1 superfamily)
  4. 2598800Superfamily l.1.1: Tags [310607] (1 family) (S)
  5. 2598801Family l.1.1.1: Tags [310682] (2 proteins)
  6. 2605870Protein N-terminal Tags [310894] (1 species)
  7. 2605871Species Synthetic [311501] (12135 PDB entries)
  8. 3047894Domain d5vp1b2: 5vp1 B:575-577 [347956]
    Other proteins in same PDB: d5vp1a_, d5vp1b1, d5vp1c_
    complexed with 9ga, mg, zn

Details for d5vp1b2

PDB Entry: 5vp1 (more details), 1.86 Å

PDB Description: discovery of clinical candidate n-{(1s)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3- dihydropyrido[2,3-b]pyrazine-4(1h)-carboxamide (tak-915), a highly potent, selective, and brain-penetrating phosphodiesterase 2a inhibitor for the treatment of cognitive disorders
PDB Compounds: (B:) cGMP-dependent 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d5vp1b2:

Sequence; same for both SEQRES and ATOM records: (download)

>d5vp1b2 l.1.1.1 (B:575-577) N-terminal Tags {Synthetic}

SCOPe Domain Coordinates for d5vp1b2:

Click to download the PDB-style file with coordinates for d5vp1b2.
(The format of our PDB-style files is described here.)

Timeline for d5vp1b2:

  • d5vp1b2 appears in periodic updates to SCOPe 2.07 starting on 2018-04-06

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