Lineage for d5vp1b1 (5vp1 B:578-916)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2342123Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2342124Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2342564Family a.211.1.0: automated matches [191566] (1 protein)
    not a true family
  6. 2342565Protein automated matches [190983] (9 species)
    not a true protein
  7. 2342579Species Human (Homo sapiens) [TaxId:9606] [188676] (127 PDB entries)
  8. 3047893Domain d5vp1b1: 5vp1 B:578-916 [347955]
    Other proteins in same PDB: d5vp1b2
    automated match to d5vp0b_
    complexed with 9ga, mg, zn

Details for d5vp1b1

PDB Entry: 5vp1 (more details), 1.86 Å

PDB Description: discovery of clinical candidate n-{(1s)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3- dihydropyrido[2,3-b]pyrazine-4(1h)-carboxamide (tak-915), a highly potent, selective, and brain-penetrating phosphodiesterase 2a inhibitor for the treatment of cognitive disorders
PDB Compounds: (B:) cGMP-dependent 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d5vp1b1:

Sequence; same for both SEQRES and ATOM records: (download)

>d5vp1b1 a.211.1.0 (B:578-916) automated matches {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d5vp1b1:

Click to download the PDB-style file with coordinates for d5vp1b1.
(The format of our PDB-style files is described here.)

Timeline for d5vp1b1:

  • d5vp1b1 appears in periodic updates to SCOPe 2.07 starting on 2018-04-06

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