SCOPe 2.08: Domain d5oi8a_: 5oi8 A:

Lineage for d5oi8a_ (5oi8 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.2: Retroviral integrase, catalytic domain [53107] (2 proteins)
   Pfam PF00665

6. Protein Retroviral integrase, catalytic domain [53108] (5 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [53110] (74 PDB entries)

8. Domain d5oi8a_: 5oi8 A: [347323]
   automated match to d3vq9c_
   complexed with 9vn, mg, so4

Details for d5oi8a_

PDB Entry: 5oi8, 2.35 Å

PDB Description: dissociation of biochemical and antiretroviral activities of integrase-ledgf allosteric inhibitors revealed by resistance of a125 polymorphic hiv-1

PDB Compounds: (A:) pol protein

SCOPe Domain Sequences for d5oi8a_:

Sequence, based on SEQRES records:

>d5oi8a_ c.55.3.2 (A:) Retroviral integrase, catalytic domain {Human immunodeficiency virus type 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsaavkaacwwagikqefgipynpqsqgvvesmnkelkkiigqvrdqaehlktav
qmavfihnkkrkggiggysagerivdiiatdi

Sequence, based on observed residues (ATOM records):

>d5oi8a_ c.55.3.2 (A:) Retroviral integrase, catalytic domain {Human immunodeficiency virus type 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsaavkaacwwagikqmnkelkkiigqvrdqaehlktavqmavfihnkkrkysag
erivdiiatdi

Timeline for d5oi8a_:

• d5oi8a_ first appeared in SCOPe 2.07