SCOP 1.69: Domain d1dx4a_: 1dx4 A:

Lineage for d1dx4a_ (1dx4 A:)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (32 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (5 proteins)

6. Protein Acetylcholinesterase [53476] (5 species)

7. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [53481] (3 PDB entries)

8. Domain d1dx4a_: 1dx4 A: [34622]

Details for d1dx4a_

PDB Entry: 1dx4, 2.7 Å

PDB Description: ache from drosophila melanogaster complex with tacrine derivative 9- (3-phenylmethylamino)-1,2,3,4-tetrahydroacridine

SCOP Domain Sequences for d1dx4a_:

Sequence, based on SEQRES records:

>d1dx4a_ c.69.1.1 (A:) Acetylcholinesterase {Fruit fly (Drosophila melanogaster)}
drlvvqtssgpvrgrsvtvqgrevhvytgipyakppvedlrfrkpvpaepwhgvldatgl
satcvqeryeyfpgfsgeeiwnpntnvsedclyinvwapakarlrhgrganggehpngkq
adtdhlihngnpqnttnglpiliwiygggfmtgsatldiynadimaavgnvivasfqyrv
gafgflhlapempsefaeeapgnvglwdqalairwlkdnahafggnpewmtlfgesagss
svnaqlmspvtrglvkrgmmqsgtmnapwshmtsekaveigkalindcncnasmlktnpa
hvmscmrsvdaktisvqqwnsysgilsfpsaptidgaflpadpmtlmktadlkdydilmg
nvrdegtyfllydfidyfdkddatalprdkyleimnnifgkatqaereaiifqytswegn
pgyqnqqqigravgdhfftcptneyaqalaergasvhyyyfthrtstslwgewmgvlhgd
eieyffgqplnnslqyrpverelgkrmlsaviefaktgnpaqdgeewpnfskedpvyyif
stddkieklargplaarcsfwndylpkvrsw

Sequence, based on observed residues (ATOM records):

>d1dx4a_ c.69.1.1 (A:) Acetylcholinesterase {Fruit fly (Drosophila melanogaster)}
drlvvqtssgpvrgrsvtvqgrevhvytgipyakppvedlrfrkpvpaepwhgvldatgl
satcvqeryeyfpgfsgeeiwnpntnvsedclyinvwapattnglpiliwiygggfmtgs
atldiynadimaavgnvivasfqyrvgafgflhlapempsefaeeapgnvglwdqalair
wlkdnahafggnpewmtlfgesagsssvnaqlmspvtrglvkrgmmqsgtmnapwshmts
ekaveigkalindcncnasmlktnpahvmscmrsvdaktisvqqwnsysgilsfpsapti
dgaflpadpmtlmktadlkdydilmgnvrdegtyfllydfidyfdkddatalprdkylei
mnnifgkatqaereaiifqytswegnpgyqnqqqigravgdhfftcptneyaqalaerga
svhyyyfthrtstslwgewmgvlhgdeieyffgqplnnslqyrpverelgkrmlsavief
aktgnpaqdgeewpnfskedpvyyifstddkieklargplaarcsfwndylpkvrsw

Timeline for d1dx4a_:

• d1dx4a_ first appeared (with stable ids) in SCOP 1.55
  
• d1dx4a_ appears in SCOP 1.67
  
• d1dx4a_ appears in SCOP 1.71
  
• d1dx4a_ appears in the current release, SCOPe 2.08