SCOPe 2.08: Family e.8.1.8: Splicing factor Prp8 RT domain

Lineage for Family e.8.1.8: Splicing factor Prp8 RT domain

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.8: Splicing factor Prp8 RT domain [345981] (2 proteins)
   Pfam PF10598, Pfam PF10597. Includes linker domain discussed in PubMed 23354046
   Homology to retroviral RT domains discussed in PubMed 21441348

Proteins:

1. Pre-mRNA splicing factor 8, Prp8 / Spp42 [346115] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [346406] (1 PDB entry)

   2. Species Schizosaccharomyces pombe 972h- [TaxId:284812] [346407] (1 PDB entry)

2. automated matches [346116] (1 species)
   not a true protein

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346408] (1 PDB entry)

More info for Family e.8.1.8: Splicing factor Prp8 RT domain

Timeline for Family e.8.1.8: Splicing factor Prp8 RT domain:

• Family e.8.1.8: Splicing factor Prp8 RT domain first appeared in SCOPe 2.07