SCOPe 2.08: Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Lineage for Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (11 families)

5. Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains [345951] (10 proteins)
   N-terminal part of Pfam PF06272
   Described in PubMed 15180986 as 'HAM (HEAT analagous motif) domain'
   Probably homologous to TPR rather than HEAT, based on PubMed 15790418
   this is a repeat family; one repeat unit is 4cr2 O:123-163 found in domain

Proteins:

1. COP9 signalosome complex subunit 1 (CSN1), N-terminal domain [346031] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [346193] (1 PDB entry)

2. COP9 signalosome complex subunit 7 (CSN7), N-terminal domain [346032] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [346194] (1 PDB entry)

3. Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [346010] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [346153] (1 PDB entry)
     Uniprot Q9UBQ5

4. Proteasome regulatory subunit Rpn12, N-terminal domain [346033] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346195] (1 PDB entry)

5. Proteasome regulatory subunit Rpn3, N-terminal domain [346034] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346196] (1 PDB entry)

6. Proteasome regulatory subunit Rpn5, N-terminal domain [346035] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346197] (1 PDB entry)

7. Proteasome regulatory subunit Rpn6, N-terminal domain [346036] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346198] (1 PDB entry)

   2. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [346199] (2 PDB entries)

8. Proteasome regulatory subunit Rpn7, N-terminal domain [346037] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346200] (1 PDB entry)

9. Proteasome regulatory subunit Rpn9, N-terminal domain [346038] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [346201] (1 PDB entry)

10. automated matches [346039] (1 species)
    not a true protein

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [346202] (1 PDB entry)

More info for Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Timeline for Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains:

• Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains first appeared in SCOPe 2.07