SCOPe 2.08: Domain d5o9zv_: 5o9z v:

Lineage for d5o9zv_ (5o9z v:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (28 families)

5. Family a.118.1.2: HEAT repeat [48385] (3 proteins)
   Pfam PF02985
   this is a repeat family; one repeat unit is 1b3u A:295-335 found in domain

6. Protein Splicing factor 3B subunit 1, HEAT repeats [346023] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [346183] (1 PDB entry)

8. Domain d5o9zv_: 5o9z v: [345819]
   Other proteins in same PDB: d5o9ze1, d5o9ze2, d5o9zg_, d5o9zh1, d5o9zh2, d5o9zi_, d5o9zk_, d5o9zp_, d5o9zx_, d5o9zy_
   protein/RNA complex
   applies to all domains of a family if the common domain is composed of a different number of small repeating units

Details for d5o9zv_

PDB Entry: 5o9z

PDB Description: cryo-em structure of a pre-catalytic human spliceosome primed for activation (b complex)

PDB Compounds: (v:) Splicing factor 3B subunit 1

SCOPe Domain Sequences for d5o9zv_:

Sequence, based on SEQRES records:

>d5o9zv_ a.118.1.2 (v:) Splicing factor 3B subunit 1, HEAT repeats {Human (Homo sapiens) [TaxId: 9606]}
eqkerkimklllkikngtppmrkaalrqitdkarefgagplfnqilpllmsptledqerh
llvkvidrilyklddlvrpyvhkilvviepllidedyyarvegreiisnlakaaglatmi
stmrpdidnmdeyvrnttarafavvasalgipsllpflkavckskkswqarhtgikivqq
iailmgcailphlrslveiiehglvdeqqkvrtisalaiaalaeaatpygiesfdsvlkp
lwkgirqhrgkglaaflkaigyliplmdaeyanyytrevmlilirefqspdeemkkivlk
vvkqccgtdgveanyikteilppffkhfwqhrmaldrrnyrqlvdttvelankvgaaeii
srivddlkdeaeqyrkmvmetiekimgnlgaadidhkleeqlidgilyafqeqttedsvm
lngfgtvvnalgkrvkpylpqicgtvlwrlnnksakvrqqaadlisrtavvmktcqeekl
mghlgvvlyeylgeeypevlgsilgalkaivnvigmhkmtppikdllprltpilknrhek
vqencidlvgriadrgaeyvsarewmricfellellkahkkairratvntfgyiakaigp
hdvlatllnnlkvqerqnrvcttvaiaivaetcspftvlpalmneyrvpelnvqngvlks
lsflfeyigemgkdyiyavtplledalmdrdlvhrqtasavvqhmslgvygfgcedslnh
llnyvwpnvfetsphviqavmgaleglrvaigpcrmlqyclqglfhparkvrdvywkiyn
siyigsqdaliahypriynddkntyiryeldyil

Sequence, based on observed residues (ATOM records):

>d5o9zv_ a.118.1.2 (v:) Splicing factor 3B subunit 1, HEAT repeats {Human (Homo sapiens) [TaxId: 9606]}
eqkerkimklllkikngtppmrkaalrqitdkarefgagplfnqilpllmsptledqerh
llvkvidrilyklddlvrpyvhkilvviepllidedyyarvegreiisnlakaaglatmi
stmrpdidnmdeyvrnttarafavvasalgipsllpflkavckskkswqarhtgikivqq
iailmgcailphlrslveiiehglvdeqqkvrtisalaiaalaeaatpygiesfdsvlkp
lwkgirqhrgkglaaflkaigyliplmdaeyanyytrevmlilirefqspdeemkkivlk
vvkqccgtdgveanyikteilppffkhfwqhrmaldrrnyrqlvdttvelankvgaaeii
srivddlkdeaeqyrkmvmetiekimgnlgaadidhkleeqlidgilyafqeqttedsvm
lngfgtvvnalgkrvkpylpqicgtvlwrlnnksakvrqqaadlisrtavvmktcqeekl
mghlgvvlyeylgeeypevlgsilgalkaivnvigmhkmtppikdllprltpilknrhek
vqencidlvgriadrgaeyvsarewmricfellellkahkkairratvntfgyiakaigp
hdvlatllnnrvcttvaiaivaetcspftvlpalmneyrvpelnvqngvlkslsflfeyi
gemgkdyiyavtplledalmdrdlvhrqtasavvqhmslgvygfgcedslnhllnyvwpn
vfetsphviqavmgaleglrvaigpcrmlqyclqglfhparkvrdvywkiynsiyigsqd
aliahypriynddkntyiryeldyil

Timeline for d5o9zv_:

• d5o9zv_ first appeared in SCOPe 2.07