SCOPe 2.08: Domain d5o9zh2: 5o9z H:36-333

Lineage for d5o9zh2 (5o9z H:36-333)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.183: Nop domain [89123] (1 superfamily)
   multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain

4. Superfamily a.183.1: Nop domain [89124] (2 families)

5. Family a.183.1.1: Nop domain [89125] (2 proteins)
   putative snoRNA binding domain

6. Protein U4/U6 small nuclear ribonucleoprotein Prp31 [158762] (2 species)
   contains insertion of a small 4-helical bundle at the tip of a long alpha-hairpin arm; this insertion approximately corresponds to the NOSIC (NUC001) domain; Pfam PF08060

7. Species Human (Homo sapiens) [TaxId:9606] [158763] (2 PDB entries)
   Uniprot Q8WWY3 85-333

8. Domain d5o9zh2: 5o9z H:36-333 [345815]
   Other proteins in same PDB: d5o9ze1, d5o9ze2, d5o9zg_, d5o9zh1, d5o9zi_, d5o9zk_, d5o9zp_, d5o9zv_, d5o9zx_, d5o9zy_
   protein/RNA complex
   has additional subdomain(s) that are not in the common domain

Details for d5o9zh2

PDB Entry: 5o9z

PDB Description: cryo-em structure of a pre-catalytic human spliceosome primed for activation (b complex)

PDB Compounds: (H:) U4/U6 small nuclear ribonucleoprotein Prp31

SCOPe Domain Sequences for d5o9zh2:

Sequence; same for both SEQRES and ATOM records:

>d5o9zh2 a.183.1.1 (H:36-333) U4/U6 small nuclear ribonucleoprotein Prp31 {Human (Homo sapiens) [TaxId: 9606]}
qeetqldlsgdsvktiaklwdskmfaeimmkieeyiskqakasevmgpveaapeyrvivd
annltveienelniihkfirdkyskrfpeleslvpnaldyirtvkelgnsldkcknnenl
qqiltnatimvvsvtasttqgqqlseeelerleeacdmalelnaskhriyeyvesrmsfi
apnlsiiigastaakimgvaggltnlskmpacnimllgaqrktlsgfsstsvlphtgyiy
hsdivqslppdlrrkaarlvaakctlaarvdsfhestegkvgyelkdeierkfdkwqe

Timeline for d5o9zh2:

• d5o9zh2 first appeared in SCOPe 2.07