SCOPe 2.08: Domain d5c03a_: 5c03 A:

Lineage for d5c03a_ (5c03 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5c03a_: 5c03 A: [345568]
   automated match to d5tkdb_
   complexed with ags, edo, gol, mg

Details for d5c03a_

PDB Entry: 5c03, 1.9 Å

PDB Description: crystal structure of kinase

PDB Compounds: (A:) Non-receptor tyrosine-protein kinase TYK2

SCOPe Domain Sequences for d5c03a_:

Sequence, based on SEQRES records:

>d5c03a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsfhrvdqkeitqlshlgqgtrtnvyegrlrvegsgdpeegkmddedplvpgrdrgqelr
vvlkvldpshhdialafyetaslmsqvshthlafvhgvcvrgpenimvteyvehgpldvw
lrrerghvpmawkmvvaqqlasalsylenknlvhgnvcgrnillarlglaegtspfikls
dpgvglgalsreerveripwlapeclpgganslstamdkwgfgatlleicfdgeaplqsr
spsekehfyqrqhrlpepscpqlatltsqcltyeptqrpsfrtilrdltrl

Sequence, based on observed residues (ATOM records):

>d5c03a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsfhrvdqkeitqlshlgqgtrtnvyegrlrelrvvlkvldpshhdialafyetaslmsq
vshthlafvhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsy
lenknlvhgnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapecl
plstamdkwgfgatlleicfdgeaplqsrspsekehfyqrqhrlpepscpqlatltsqcl
tyeptqrpsfrtilrdltrl

Timeline for d5c03a_:

• d5c03a_ first appeared in SCOPe 2.07