SCOPe 2.08: Domain d4pmpa1: 4pmp A:501-787

Lineage for d4pmpa1 (4pmp A:501-787)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4pmpa1: 4pmp A:501-787 [345400]
   Other proteins in same PDB: d4pmpa2
   automated match to d5ut3a_
   complexed with 31w, act, cl

Details for d4pmpa1

PDB Entry: 4pmp, 1.8 Å

PDB Description: The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea

PDB Compounds: (A:) high affinity nerve growth factor receptor

SCOPe Domain Sequences for d4pmpa1:

Sequence, based on SEQRES records:

>d4pmpa1 d.144.1.0 (A:501-787) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cvhhikrrdivlkwelgegafgkvflaechnllpeqdkmlvavkalkeasesarqdfqre
aelltmlqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapg
plglgqllavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsrdiystdy
yrvggrtmlpirwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidci
tqgrelerpracppevyaimrgcwqrepqqrhsikdvharlqalaqa

Sequence, based on observed residues (ATOM records):

>d4pmpa1 d.144.1.0 (A:501-787) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cvhhikrrdivlkwelgegafgkvflaechnllkmlvavkalksarqdfqreaelltmlq
hqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapgplglgqll
avasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsriystdyyrvgtmlpi
rwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidcitqgrelerpra
cppevyaimrgcwqrepqqrhsikdvharlqalaqa

Timeline for d4pmpa1:

• d4pmpa1 first appeared in SCOPe 2.07