SCOPe 2.07: Domain d4oo8d1: 4oo8 D:3-58,D:718-765,D:919-1102

Lineage for d4oo8d1 (4oo8 D:3-58,D:718-765,D:919-1102)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (16 families)
   consists of one domain of this fold

5. Family c.55.3.16: RuvC-like domain from CRISPR-associated protein Cas9 [345969] (1 protein)
   Homology to RuvC noted in PubMed 21756346

6. Protein CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain [346086] (3 species)

7. Species Streptococcus pyogenes [TaxId:301447] [346314] (2 PDB entries)

8. Domain d4oo8d1: 4oo8 D:3-58,D:718-765,D:919-1102 [345383]
   Other proteins in same PDB: d4oo8a2, d4oo8a3, d4oo8a4, d4oo8d2, d4oo8d3
   automated match to d4oo8a1
   protein/DNA complex; protein/RNA complex

Details for d4oo8d1

PDB Entry: 4oo8, 2.5 Å

PDB Description: crystal structure of streptococcus pyogenes cas9 in complex with guide rna and target dna

PDB Compounds: (D:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4oo8d1:

Sequence, based on SEQRES records:

>d4oo8d1 c.55.3.16 (D:3-58,D:718-765,D:919-1102) CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain {Streptococcus pyogenes [TaxId: 301447]}
kkysiglaigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetXdsl
hehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarXrqlvetrqitkhva
qildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhhahdaylnav
vgtalikkypklesefvygdykvydvrkmiakseqeigkatakyffysnimnffkteitl
angeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqt

Sequence, based on observed residues (ATOM records):

>d4oo8d1 c.55.3.16 (D:3-58,D:718-765,D:919-1102) CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain {Streptococcus pyogenes [TaxId: 301447]}
kkysiglaigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetXdsl
hehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarXrqlvetrqitkhva
qildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhhahdaylnav
vgtalikkypklesefvygdfysnimnffklietngetgeivwdkgrdfatvrkvlsmpq
vnivkktevqt

Timeline for d4oo8d1:

• d4oo8d1 is new in SCOPe 2.07-stable
  
• d4oo8d1 appears in the current release, SCOPe 2.08