SCOPe 2.08: Domain d4oo8a4: 4oo8 A:1103-1366

Lineage for d4oo8a4 (4oo8 A:1103-1366)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.80: CRISPR-associated endonuclease Cas9/Csn1, Protospace-adjacent motif (PAM)-interacting domain [345893] (1 superfamily)
   N-terminal part is structurally divergent wedge domain; middle domain is homologous to DNA gyrase B and Topoisomerase II; C-terminal domain appears to be Cas9-specific

4. Superfamily e.80.1: CRISPR-associated endonuclease Cas9/Csn1, PAM-interacting (PI) domain [345926] (1 family)
   Pfam PF16595

5. Family e.80.1.1: CRISPR-associated endonuclease Cas9/Csn1, PAM-interacting (PI) domain [345982] (1 protein)

6. Protein CRISPR-associated endonuclease Cas9/Csn1, PI domain [346119] (3 species)

7. Species Streptococcus pyogenes [TaxId:301447] [346418] (2 PDB entries)

8. Domain d4oo8a4: 4oo8 A:1103-1366 [345382]
   Other proteins in same PDB: d4oo8a1, d4oo8a2, d4oo8a3, d4oo8d1, d4oo8d2
   protein/DNA complex; protein/RNA complex

Details for d4oo8a4

PDB Entry: 4oo8, 2.5 Å

PDB Description: crystal structure of streptococcus pyogenes cas9 in complex with guide rna and target dna

PDB Compounds: (A:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4oo8a4:

Sequence, based on SEQRES records:

>d4oo8a4 e.80.1.1 (A:1103-1366) CRISPR-associated endonuclease Cas9/Csn1, PI domain {Streptococcus pyogenes [TaxId: 301447]}
ggfskesilpkrnsdkliarkkdwdpkkyggfdsptvaysvlvvakvekgkskklksvke
llgitimerssfeknpidfleakgykevkkdliiklpkyslfelengrkrmlasagelqk
gnelalpskyvnflylashyeklkgspedneqkqlfveqhkhyldeiieqisefskrvil
adanldkvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidrkrytstkev
ldatlihqsitglyetridlsqlg

Sequence, based on observed residues (ATOM records):

>d4oo8a4 e.80.1.1 (A:1103-1366) CRISPR-associated endonuclease Cas9/Csn1, PI domain {Streptococcus pyogenes [TaxId: 301447]}
ggfskesilpkrnsdkliarkkdwdpkkyggfdsptvaysvlvvakvekgkskklksvke
llgitimerssfeknpidfleakgykevkkdliiklpkyslfelengrkrmlasagelqk
gnelalpskyvnflylashypedneqkqlfveqhkhyldeiieqisefskrviladanld
kvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidrkrytstkevldatli
hqsitglyetridlsqlg

Timeline for d4oo8a4:

• d4oo8a4 first appeared in SCOPe 2.07