Lineage for d4oo8a2 (4oo8 A:775-907)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2535017Fold d.4: His-Me finger endonucleases [54059] (1 superfamily)
    core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
  4. 2535018Superfamily d.4.1: His-Me finger endonucleases [54060] (8 families) (S)
    common motif contains conserved histidine residue and metal-binding site
  5. 2535160Family d.4.1.8: HNH domain from CRISPR-associated protein Cas9 [345970] (1 protein)
    Homology to HNH nucleases noted in PubMed 21756346
    Pfam PF13395
  6. 2535161Protein CRISPR-associated endonuclease Cas9/Csn1, HNH domain [346090] (3 species)
  7. 2535166Species Streptococcus pyogenes [TaxId:301447] [346348] (2 PDB entries)
  8. 2535167Domain d4oo8a2: 4oo8 A:775-907 [345380]
    Other proteins in same PDB: d4oo8a1, d4oo8a3, d4oo8a4, d4oo8d1, d4oo8d2, d4oo8d3
    protein/DNA complex; protein/RNA complex

Details for d4oo8a2

PDB Entry: 4oo8 (more details), 2.5 Å

PDB Description: crystal structure of streptococcus pyogenes cas9 in complex with guide rna and target dna
PDB Compounds: (A:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4oo8a2:

Sequence, based on SEQRES records: (download)

>d4oo8a2 d.4.1.8 (A:775-907) CRISPR-associated endonuclease Cas9/Csn1, HNH domain {Streptococcus pyogenes [TaxId: 301447]}
knsrermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrls
dydvdaivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitq
rkfdnltkaergg

Sequence, based on observed residues (ATOM records): (download)

>d4oo8a2 d.4.1.8 (A:775-907) CRISPR-associated endonuclease Cas9/Csn1, HNH domain {Streptococcus pyogenes [TaxId: 301447]}
knsrermkrieegikelgsentqlqneklylyylqngrdmyvdqeldinrlsdydvdaiv
pqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitqrkfdnltk
aergg

SCOPe Domain Coordinates for d4oo8a2:

Click to download the PDB-style file with coordinates for d4oo8a2.
(The format of our PDB-style files is described here.)

Timeline for d4oo8a2: