SCOPe 2.08: Domain d4oo8a2: 4oo8 A:775-907

Lineage for d4oo8a2 (4oo8 A:775-907)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.4: His-Me finger endonucleases [54059] (1 superfamily)
   core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures

4. Superfamily d.4.1: His-Me finger endonucleases [54060] (8 families)
   common motif contains conserved histidine residue and metal-binding site

5. Family d.4.1.8: HNH domain from CRISPR-associated protein Cas9 [345970] (1 protein)
   Homology to HNH nucleases noted in PubMed 21756346
   Pfam PF13395

6. Protein CRISPR-associated endonuclease Cas9/Csn1, HNH domain [346090] (3 species)

7. Species Streptococcus pyogenes [TaxId:301447] [346348] (2 PDB entries)

8. Domain d4oo8a2: 4oo8 A:775-907 [345380]
   Other proteins in same PDB: d4oo8a1, d4oo8a3, d4oo8a4, d4oo8d1, d4oo8d2, d4oo8d3
   protein/DNA complex; protein/RNA complex

Details for d4oo8a2

PDB Entry: 4oo8, 2.5 Å

PDB Description: crystal structure of streptococcus pyogenes cas9 in complex with guide rna and target dna

PDB Compounds: (A:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4oo8a2:

Sequence, based on SEQRES records:

>d4oo8a2 d.4.1.8 (A:775-907) CRISPR-associated endonuclease Cas9/Csn1, HNH domain {Streptococcus pyogenes [TaxId: 301447]}
knsrermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrls
dydvdaivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitq
rkfdnltkaergg

Sequence, based on observed residues (ATOM records):

>d4oo8a2 d.4.1.8 (A:775-907) CRISPR-associated endonuclease Cas9/Csn1, HNH domain {Streptococcus pyogenes [TaxId: 301447]}
knsrermkrieegikelgsentqlqneklylyylqngrdmyvdqeldinrlsdydvdaiv
pqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitqrkfdnltk
aergg

Timeline for d4oo8a2:

• d4oo8a2 first appeared in SCOPe 2.07