SCOPe 2.08: Domain d4lctd1: 4lct D:32-324

Lineage for d4lctd1 (4lct D:32-324)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (11 families)

5. Family a.118.8.9: TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains [345951] (10 proteins)
   N-terminal part of Pfam PF06272
   Described in PubMed 15180986 as 'HAM (HEAT analagous motif) domain'
   Probably homologous to TPR rather than HEAT, based on PubMed 15790418
   this is a repeat family; one repeat unit is 4cr2 O:123-163 found in domain

6. Protein COP9 signalosome complex subunit 1 (CSN1), N-terminal domain [346031] (1 species)

7. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [346193] (1 PDB entry)

8. Domain d4lctd1: 4lct D:32-324 [345333]
   Other proteins in same PDB: d4lcta2, d4lctb2, d4lctc2, d4lctd2
   complexed with so4

Details for d4lctd1

PDB Entry: 4lct, 2.7 Å

PDB Description: Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1

PDB Compounds: (D:) COP9 signalosome complex subunit 1

SCOPe Domain Sequences for d4lctd1:

Sequence; same for both SEQRES and ATOM records:

>d4lctd1 a.118.8.9 (D:32-324) COP9 signalosome complex subunit 1 (CSN1), N-terminal domain {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}
epldieayaalykgrtkimrllfianhcggnhalqfdalrmaydeikkgentqlfrevvn
kignrlgekygmdlawceavdrraeqkkvklenelssyrtnlikesirmgyndfgdfyya
cgmlgdafknyirtrdyctttkhiihmcmnailvsiemgqfthvtsyvnkaeqnpetlep
mvnaklrcasglahlelkkyklaarkfldvnpelgnsyneviapqdiatygglcalasfd
rselkqkvidninfrnflelvpdvrelindfyssryascleylaslksnllld

Timeline for d4lctd1:

• d4lctd1 first appeared in SCOPe 2.07