SCOPe 2.08: Domain d4cmpa4: 4cmp A:1137-1363

Lineage for d4cmpa4 (4cmp A:1137-1363)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.80: CRISPR-associated endonuclease Cas9/Csn1, Protospace-adjacent motif (PAM)-interacting domain [345893] (1 superfamily)
   N-terminal part is structurally divergent wedge domain; middle domain is homologous to DNA gyrase B and Topoisomerase II; C-terminal domain appears to be Cas9-specific

4. Superfamily e.80.1: CRISPR-associated endonuclease Cas9/Csn1, PAM-interacting (PI) domain [345926] (1 family)
   Pfam PF16595

5. Family e.80.1.1: CRISPR-associated endonuclease Cas9/Csn1, PAM-interacting (PI) domain [345982] (1 protein)

6. Protein CRISPR-associated endonuclease Cas9/Csn1, PI domain [346119] (3 species)

7. Species Streptococcus pyogenes [TaxId:301447] [346418] (2 PDB entries)

8. Domain d4cmpa4: 4cmp A:1137-1363 [345147]
   Other proteins in same PDB: d4cmpa1, d4cmpa2, d4cmpa3, d4cmpb1, d4cmpb2, d4cmpb3
   complexed with mg, so4

Details for d4cmpa4

PDB Entry: 4cmp, 2.62 Å

PDB Description: Crystal structure of S. pyogenes Cas9

PDB Compounds: (A:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4cmpa4:

Sequence, based on SEQRES records:

>d4cmpa4 e.80.1.1 (A:1137-1363) CRISPR-associated endonuclease Cas9/Csn1, PI domain {Streptococcus pyogenes [TaxId: 301447]}
ptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdlii
klpkyslfelengrkrmlasagelqkgnelalpskyvnflylashyeklkgspedneqkq
lfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftlt
nlgapaafkyfdttidrkrytstkevldatlihqsitglyetridls

Sequence, based on observed residues (ATOM records):

>d4cmpa4 e.80.1.1 (A:1137-1363) CRISPR-associated endonuclease Cas9/Csn1, PI domain {Streptococcus pyogenes [TaxId: 301447]}
ptvaysvlvvsvkellgitimerssfeknpidfleakgkdliiklpkyslfelengrkrm
lasagelqkgnelalpskyvnflylashyveqhkhyldeiieqisefskrviladanldk
vlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidrkrytstkevldatlih
qsitglyetridls

Timeline for d4cmpa4:

• d4cmpa4 first appeared in SCOPe 2.07