SCOPe 2.08: Domain d4cmpa1: 4cmp A:4-58,A:718-764,A:908-1102

Lineage for d4cmpa1 (4cmp A:4-58,A:718-764,A:908-1102)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.16: RuvC-like domain from CRISPR-associated protein Cas9 [345969] (1 protein)
   Homology to RuvC noted in PubMed 21756346
   Pfam PF18541

6. Protein CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain [346086] (3 species)

7. Species Streptococcus pyogenes [TaxId:301447] [346314] (2 PDB entries)

8. Domain d4cmpa1: 4cmp A:4-58,A:718-764,A:908-1102 [345144]
   Other proteins in same PDB: d4cmpa2, d4cmpa3, d4cmpa4, d4cmpb2, d4cmpb3, d4cmpb4
   complexed with mg, so4

Details for d4cmpa1

PDB Entry: 4cmp, 2.62 Å

PDB Description: Crystal structure of S. pyogenes Cas9

PDB Compounds: (A:) crispr-associated endonuclease cas9/csn1

SCOPe Domain Sequences for d4cmpa1:

Sequence, based on SEQRES records:

>d4cmpa1 c.55.3.16 (A:4-58,A:718-764,A:908-1102) CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain {Streptococcus pyogenes [TaxId: 301447]}
kysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetXdslh
ehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemaXlseldkagfikrqlve
trqitkhvaqildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhh
ahdaylnavvgtalikkypklesefvygdykvydvrkmiakseqeigkatakyffysnim
nffkteitlangeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqt

Sequence, based on observed residues (ATOM records):

>d4cmpa1 c.55.3.16 (A:4-58,A:718-764,A:908-1102) CRISPR-associated endonuclease Cas9/Csn1, RuvC-like domain {Streptococcus pyogenes [TaxId: 301447]}
kysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetXdslh
ehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemaXlseldkagfikrqlve
trqitkhvaqildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhh
ahdaylnavvgtalikkypklesefvygdykvydvrkmiakseqyffysnimnffkteit
langeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqt

Timeline for d4cmpa1:

• d4cmpa1 first appeared in SCOPe 2.07