SCOPe 2.08: Domain d3ihya1: 3ihy A:532-871

Lineage for d3ihya1 (3ihy A:532-871)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d3ihya1: 3ihy A:532-871 [344784]
   Other proteins in same PDB: d3ihya2

Details for d3ihya1

PDB Entry: 3ihy, 2.8 Å

PDB Description: human pik3c3 crystal structure

PDB Compounds: (A:) Phosphatidylinositol 3-kinase catalytic subunit type 3

SCOPe Domain Sequences for d3ihya1:

Sequence; same for both SEQRES and ATOM records:

>d3ihya1 d.144.1.4 (A:532-871) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dksvrvmrsllaaqqtfvdrlvhlmkavqresgnrkkknerlqallgdnekmnlsdveli
plplepqvkirgiipetatlfksalmpaqlffktedggkypvifkhgddlrqdqlilqii
slmdkllrkenldlkltpykvlatstkhgfmqfiqsvpvaevldtegsiqnffrkyapse
ngpngisaevmdtyvkscagycvityilgvgdrhldnllltktgklfhidfgyilgrdpk
plpppmklnkemvegmggtqseqyqefrkqcytaflhlrrysnlilnlfslmvdanipdi
alepdktvkkvqdkfrldlsdeeavhymqslidesvhalf

Timeline for d3ihya1:

• d3ihya1 first appeared in SCOPe 2.07