SCOPe 2.08: Domain d2gk6a1: 2gk6 A:295-324,A:416-702

Lineage for d2gk6a1 (2gk6 A:295-324,A:416-702)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.19: Tandem AAA-ATPase domain [81268] (41 proteins)
   duplication: tandem repeat of two RecA-like (AAA) domains

6. Protein Upf1, N-terminal domain [419078] (1 species)
   this first domain includes small helical insert subdomain

7. Species Human (Homo sapiens) [TaxId:9606] [419570] (3 PDB entries)

8. Domain d2gk6a1: 2gk6 A:295-324,A:416-702 [344573]
   Other proteins in same PDB: d2gk6a2, d2gk6a3, d2gk6a4, d2gk6b2, d2gk6b3, d2gk6b4
   automated match to d2gjka1
   complexed with adp, mg, po4
   has additional subdomain(s) that are not in the common domain

Details for d2gk6a1

PDB Entry: 2gk6, 2.4 Å

PDB Description: Structural and Functional insights into the human Upf1 helicase core

PDB Compounds: (A:) Regulator of nonsense transcripts 1

SCOPe Domain Sequences for d2gk6a1:

Sequence, based on SEQRES records:

>d2gk6a1 c.37.1.19 (A:295-324,A:416-702) Upf1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
ryedayqyqnifgplvkleadydkklkesqXkstsfdrmqsalktfavdetsvsgyiyhk
llghevedviikcqlpkrftaqglpdlnhsqvyavktvlqrplsliqgppgtgktvtsat
ivyhlarqgngpvlvcapsniavdqltekihqtglkvvrlcaksreaidspvsflalhnq
irnmdsmpelqklqqlkdetgelssadekryralkrtaerellmnadvicctcvgagdpr
lakmqfrsilidestqatepecmvpvvlgakqlilvgdhcqlgpvvmckkaakaglsqsl
ferlvvlgirpirlqvqy

Sequence, based on observed residues (ATOM records):

>d2gk6a1 c.37.1.19 (A:295-324,A:416-702) Upf1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
ryedayqyqnifgplvkleadydkklkesqXkstsfdrmqsalktfavdetsvsgyiyhk
llghevedviikcqlpkrftaqglpdlnhsqvyavktvlqrplsliqgppgtgktvtsat
ivyhlarqgngpvlvcapsniavdqltekihqtglkvvrlcaksreaidspvsflalhnq
irnmdsmpelqklqqlkdlssadekryralkrtaerellmnadvicctcvgagdprlakm
qfrsilidestqatepecmvpvvlgakqlilvgdhcqlgpvvmckkaakaglsqslferl
vvlgirpirlqvqy

Timeline for d2gk6a1:

• d2gk6a1 first appeared in SCOPe 2.07