SCOPe 2.07: Domain d5t23a4: 5t23 A:352-524

Lineage for d5t23a4 (5t23 A:352-524)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (70 PDB entries)

8. Domain d5t23a4: 5t23 A:352-524 [344397]
   Other proteins in same PDB: d5t23a1, d5t23a2, d5t23a3
   complexed with 74f

Details for d5t23a4

PDB Entry: 5t23, 2.78 Å

PDB Description: pi3kg in complex with 5d

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5t23a4:

Sequence, based on SEQRES records:

>d5t23a4 b.7.1.1 (A:352-524) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidh
rfllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldnyc

Sequence, based on observed residues (ATOM records):

>d5t23a4 b.7.1.1 (A:352-524) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvtvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsi
kikdlpkgallnlqiycqllyyvnlllidhrfllrrgeyvlhmwqisfnadkltsatnpd
kensmsisilldnyc

Timeline for d5t23a4:

• d5t23a4 is new in SCOPe 2.07-stable
  
• d5t23a4 appears in the current release, SCOPe 2.08