SCOPe 2.08: Domain d5m4na2: 5m4n A:177-366

Lineage for d5m4na2 (5m4n A:177-366)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (19 PDB entries)
   Uniprot Q15120 177-301

8. Domain d5m4na2: 5m4n A:177-366 [344358]
   Other proteins in same PDB: d5m4na1
   complexed with 7fv, cl, tf3

Details for d5m4na2

PDB Entry: 5m4n, 2.6 Å

PDB Description: application of off-rate screening in the identification of novel pan- isoform inhibitors of pyruvate dehydrogenase kinase

PDB Compounds: (A:) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d5m4na2:

Sequence, based on SEQRES records:

>d5m4na2 d.122.1.4 (A:177-366) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkals
tdsverlpvy

Sequence, based on observed residues (ATOM records):

>d5m4na2 d.122.1.4 (A:177-366) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystapyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvy

Timeline for d5m4na2:

• d5m4na2 first appeared in SCOPe 2.07