SCOPe 2.08: Domain d6bn5b2: 6bn5 B:219-524

Lineage for d6bn5b2 (6bn5 B:219-524)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein automated matches [190252] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187034] (47 PDB entries)

8. Domain d6bn5b2: 6bn5 B:219-524 [342935]
   Other proteins in same PDB: d6bn5a1, d6bn5a2, d6bn5b1
   automated match to d2shpa1
   complexed with dzj

Details for d6bn5b2

PDB Entry: 6bn5, 2.22 Å

PDB Description: non-receptor protein tyrosine phosphatase shp2 f285s in complex with allosteric inhibitor jlr-2

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d6bn5b2:

Sequence, based on SEQRES records:

>d6bn5b2 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpsdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyiet

Sequence, based on observed residues (ATOM records):

>d6bn5b2 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknknryknilpsdh
trvvlhsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergkskc
vkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqtertvwqyhfrtwpdhgvp
sdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdid
vpktiqmvrsqrsgmvqteaqyrfiymavqhyiet

Timeline for d6bn5b2:

• d6bn5b2 first appeared in SCOPe 2.06
  
• d6bn5b2 appears in SCOPe 2.07