SCOPe 2.06: Domain d6b3si2: 6b3s I:481-502

Lineage for d6b3si2 (6b3s I:481-502)

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.9: Growth factor receptor domain [57184] (2 families)

5. Family g.3.9.0: automated matches [232406] (1 protein)
   not a true family

6. Protein automated matches [232407] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [232408] (11 PDB entries)

8. Domain d6b3si2: 6b3s I:481-502 [342232]
   Other proteins in same PDB: d6b3sa1, d6b3sa2, d6b3sb1, d6b3sb3, d6b3sd1, d6b3sd2, d6b3se1, d6b3se3, d6b3sg1, d6b3sg2, d6b3si1, d6b3si3, d6b3sk1, d6b3sk2, d6b3sl1, d6b3sl2
   automated match to d1yy9a4
   complexed with bma, man, nag

Details for d6b3si2

PDB Entry: 6b3s, 2.8 Å

PDB Description: crystal structure of the fab fragment of necitumumab (fab11f8) in complex with domain iii from a cetuximab resistant variant of egfr (segfrd3-s468r)

PDB Compounds: (I:) Epidermal growth factor receptor

SCOPe Domain Sequences for d6b3si2:

Sequence; same for both SEQRES and ATOM records:

>d6b3si2 g.3.9.0 (I:481-502) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vchalcspegcwgpeprdcvsc

Timeline for d6b3si2:

• d6b3si2 is new in SCOPe 2.06-stable
  
• d6b3si2 appears in SCOPe 2.07
  
• d6b3si2 appears in the current release, SCOPe 2.08