SCOPe 2.08: Domain d6auda1: 6aud A:144-322

Lineage for d6auda1 (6aud A:144-322)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (15 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d6auda1: 6aud A:144-322 [341692]
   Other proteins in same PDB: d6auda2, d6auda3, d6auda4, d6auda5
   automated match to d1he8a3
   complexed with bwy
   has additional insertions and/or extensions that are not grouped together

Details for d6auda1

PDB Entry: 6aud, 2.02 Å

PDB Description: pi3k-gamma k802t in complex with cpd 8 10-((1-(tert-butyl)piperidin-4- yl)sulfinyl)-2-(1-isopropyl-1h-1,2,4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6auda1:

Sequence, based on SEQRES records:

>d6auda1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Sequence, based on observed residues (ATOM records):

>d6auda1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmaeqdfvlrvcg
rdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Timeline for d6auda1:

• d6auda1 first appeared in SCOPe 2.06
  
• d6auda1 appears in SCOPe 2.07