SCOPe 2.08: Domain d5mq5d_: 5mq5 D:

Lineage for d5mq5d_ (5mq5 D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.88: Glutaminase/Asparaginase [53773] (1 superfamily)
   consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
   Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
   Domain 2 has parallel beta-sheet of 4 strands, order 1234

4. Superfamily c.88.1: Glutaminase/Asparaginase [53774] (2 families)

5. Family c.88.1.1: Glutaminase/Asparaginase [53775] (4 proteins)
   automatically mapped to Pfam PF00710

6. Protein Asparaginase type II [53776] (5 species)

7. Species Escherichia coli [TaxId:562] [53777] (42 PDB entries)

8. Domain d5mq5d_: 5mq5 D: [341530]
   Other proteins in same PDB: d5mq5a2
   automated match to d1nnsa_
   complexed with asp; mutant

Details for d5mq5d_

PDB Entry: 5mq5, 1.6 Å

PDB Description: a protease-resistant n24s escherichia coli asparaginase mutant with outstanding stability and enhanced anti-leukaemic activity

PDB Compounds: (D:) L-asparaginase 2

SCOPe Domain Sequences for d5mq5d_:

Sequence, based on SEQRES records:

>d5mq5d_ c.88.1.1 (D:) Asparaginase type II {Escherichia coli [TaxId: 562]}
lpnitilatggtiagggdsatkssytvgkvgvenlvnavpqlkdianvkgeqvvnigsqd
mndnvwltlakkintdcdktdgfvithgtdtmeetayfldltvkcdkpvvmvgamrpsts
msadgpfnlynavvtaadkasanrgvlvvmndtvldgrdvtktnttdvatfksvnygplg
yihngkidyqrtparkhtsdtpfdvsklnelpkvgivynyanasdlpakalvdagydgiv
sagvgngnlyksvfdtlataaktgtavvrssrvptgattqdaevddakygfvasgtlnpq
karvllqlaltqtkdpqqiqqifnqy

Sequence, based on observed residues (ATOM records):

>d5mq5d_ c.88.1.1 (D:) Asparaginase type II {Escherichia coli [TaxId: 562]}
lpnitilatggtiaggkvgvenlvnavpqlkdianvkgeqvvnigsqdmndnvwltlakk
intdcdktdgfvithgtdtmeetayfldltvkcdkpvvmvgamrpstsmsadgpfnlyna
vvtaadkasanrgvlvvmndtvldgrdvtktnttdvatfksvnygplgyihngkidyqrt
parkhtsdtpfdvsklnelpkvgivynyanasdlpakalvdagydgivsagvgngnlyks
vfdtlataaktgtavvrssrvptgattqdaevddakygfvasgtlnpqkarvllqlaltq
tkdpqqiqqifnqy

Timeline for d5mq5d_:

• d5mq5d_ first appeared in SCOPe 2.06
  
• d5mq5d_ appears in SCOPe 2.07