SCOPe 2.06: Domain d6eqsa_: 6eqs A:

Lineage for d6eqsa_ (6eqs A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase sirtuin-5 [142128] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142129] (4 PDB entries)
   Uniprot Q9NXA8 36-302

8. Domain d6eqsa_: 6eqs A: [340912]
   Other proteins in same PDB: d6eqsc2, d6eqsd2
   automated match to d2b4ya1
   complexed with bu2, bv8, dms, edo, zn

Details for d6eqsa_

PDB Entry: 6eqs, 1.32 Å

PDB Description: human sirt5 in complex with stalled peptidylimidate intermediate of inhibitory compound 29

PDB Compounds: (A:) NAD-dependent protein deacylase sirtuin-5, mitochondrial

SCOPe Domain Sequences for d6eqsa_:

Sequence; same for both SEQRES and ATOM records:

>d6eqsa_ c.31.1.5 (A:) NAD-dependent deacetylase sirtuin-5 {Human (Homo sapiens) [TaxId: 9606]}
arpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafah
npsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtkn
lleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcg
gllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvae
fntettpatnrfrfhfqgpcgttlpeala

Timeline for d6eqsa_:

• d6eqsa_ is new in SCOPe 2.06-stable
  
• d6eqsa_ appears in SCOPe 2.07
  
• d6eqsa_ appears in the current release, SCOPe 2.08