SCOPe 2.06: Domain d5xgnb_: 5xgn B:

Lineage for d5xgnb_ (5xgn B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (90 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5xgnb_: 5xgn B: [340175]
   automated match to d3ikaa_
   complexed with 85x, cl

Details for d5xgnb_

PDB Entry: 5xgn, 3 Å

PDB Description: crystal structure of egfr 696-1022 t790m/c797s in complex with go6976

PDB Compounds: (B:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5xgnb_:

Sequence, based on SEQRES records:

>d5xgnb_ d.144.1.7 (B:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d5xgnb_ d.144.1.7 (B:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipgekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglaklekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermsptdsnfyralmvv
dadeylip

Timeline for d5xgnb_:

• d5xgnb_ is new in SCOPe 2.06-stable
  
• d5xgnb_ appears in SCOPe 2.07
  
• d5xgnb_ appears in the current release, SCOPe 2.08