SCOPe 2.07: Domain d6b4la1: 6b4l A:174-320

Lineage for d6b4la1 (6b4l A:174-320)

1. Root: SCOPe 2.07

2. Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein automated matches [190236] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188722] (88 PDB entries)

8. Domain d6b4la1: 6b4l A:174-320 [339750]
   Other proteins in same PDB: d6b4la2, d6b4lb2
   automated match to d2kbwa_
   complexed with cjy

Details for d6b4la1

PDB Entry: 6b4l, 2.25 Å

PDB Description: crystal structure of mcl-1 in complex with a bim competitive inhibitor

PDB Compounds: (A:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d6b4la1:

Sequence; same for both SEQRES and ATOM records:

>d6b4la1 f.1.4.1 (A:174-320) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgmlr
kldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaes
itdvlvrtkrdwlvkqrgwdgfveffh

Timeline for d6b4la1:

• d6b4la1 first appeared in SCOPe 2.06
  
• d6b4la1 appears in the current release, SCOPe 2.08