SCOPe 2.08: Domain d5o8va_: 5o8v A:

Lineage for d5o8va_ (5o8v A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)

8. Domain d5o8va_: 5o8v A: [338612]
   automated match to d4aaca_
   complexed with 9o2; mutant

Details for d5o8va_

PDB Entry: 5o8v, 2 Å

PDB Description: covalent inhibitor 4a bound to the lipid pocket of p38alpha mutant s251c

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d5o8va_:

Sequence, based on SEQRES records:

>d5o8va_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkicsesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppld

Sequence, based on observed residues (ATOM records):

>d5o8va_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgsvcaafdtktglrvavkklsrpfqsiihakr
tyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnniltddhvqfliy
qilrglkyihsadiihrdlkpsnlavnedcelkildvatrwyrapeimlnwmhynqtvdi
wsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkicsesarnyiqsltqmp
kmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadpydqs
fesrdllidewksltydevisfvpppld

Timeline for d5o8va_:

• d5o8va_ first appeared in SCOPe 2.06
  
• d5o8va_ appears in SCOPe 2.07