Lineage for d5o8ua_ (5o8u A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2544248Protein MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 2544249Species Human (Homo sapiens) [TaxId:9606] [56130] (202 PDB entries)
  8. 2544374Domain d5o8ua_: 5o8u A: [338598]
    automated match to d4aaca_
    complexed with 9o5; mutant

Details for d5o8ua_

PDB Entry: 5o8u (more details), 2 Å

PDB Description: covalent inhibitor 4b bound to the lipid pocket of p38alpha mutant s252c
PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d5o8ua_:

Sequence, based on SEQRES records: (download)

>d5o8ua_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkiscesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records): (download)

>d5o8ua_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvggsvcaafdtktglrvavkklsrpfqsiihakrt
yrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvq
fliyqilrglkyihsadiihrdlkpsnlavnedcelkildyvatrwyrapeimlnwmhyn
qtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkiscesarnyiqs
ltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvad
pydqsfesrdllidewksltydevisfvppp

SCOPe Domain Coordinates for d5o8ua_:

Click to download the PDB-style file with coordinates for d5o8ua_.
(The format of our PDB-style files is described here.)

Timeline for d5o8ua_: