SCOPe 2.08: Domain d5vqza2: 5vqz A:430-552

Lineage for d5vqza2 (5vqz A:430-552)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.0: automated matches [191357] (1 protein)
   not a true family

6. Protein automated matches [190396] (40 species)
   not a true protein

7. Species Human immunodeficiency virus type 1 group m subtype b (isolate bh10) [TaxId:11678] [275362] (22 PDB entries)

8. Domain d5vqza2: 5vqz A:430-552 [338361]
   Other proteins in same PDB: d5vqza1, d5vqza3, d5vqzb_
   automated match to d1dloa1
   complexed with 9hy, so4

Details for d5vqza2

PDB Entry: 5vqz, 2.23 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase (k103n, y181c) variant in complex with 2-chloro-n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n- methylacetamide (jlj686), a non-nucleoside inhibitor

PDB Compounds: (A:) Reverse transcriptase/ribonuclease H

SCOPe Domain Sequences for d5vqza2:

Sequence; same for both SEQRES and ATOM records:

>d5vqza2 c.55.3.0 (A:430-552) automated matches {Human immunodeficiency virus type 1 group m subtype b (isolate bh10) [TaxId: 11678]}
ekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqds
glevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvd
klv

Timeline for d5vqza2:

• d5vqza2 first appeared in SCOPe 2.06
  
• d5vqza2 appears in SCOPe 2.07