SCOPe 2.08: Domain d5wdyb_: 5wdy B:

Lineage for d5wdyb_ (5wdy B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Protein kinase wnk1 [111196] (2 species)
   OPK group; WNK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111197] (4 PDB entries)
   Uniprot Q9JIH7 211-480

8. Domain d5wdyb_: 5wdy B: [338065]
   automated match to d4pwna_
   complexed with a6s, anp, mn

Details for d5wdyb_

PDB Entry: 5wdy, 2.46 Å

PDB Description: crystal structure of wnk1 in complex with 1-cyclohexyl-n-({6-fluoro-1- [2-(3-methoxyphenyl)pyridin-4-yl]-1h-indol-3-yl}methyl)methanamine (compound 6)

PDB Compounds: (B:) Serine/threonine-protein kinase WNK1

SCOPe Domain Sequences for d5wdyb_:

Sequence, based on SEQRES records:

>d5wdyb_ d.144.1.7 (B:) Protein kinase wnk1 {Human (Homo sapiens) [TaxId: 9606]}
eletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqdrkltkserqrf
keeaemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkikvlr
swcrqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkradfaksvig
tpefmapemyaaaydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgvkpasfd
kvaipevkeiiegcirqnkderysikdllnhaffq

Sequence, based on observed residues (ATOM records):

>d5wdyb_ d.144.1.7 (B:) Protein kinase wnk1 {Human (Homo sapiens) [TaxId: 9606]}
eletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqltkserqrfkee
aemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkikvlrswc
rqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkrtpefmapemyaa
aydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgsfdkvaipevkeiiegcir
qnkderysikdllnhaffq

Timeline for d5wdyb_:

• d5wdyb_ first appeared in SCOPe 2.06
  
• d5wdyb_ appears in SCOPe 2.07