SCOPe 2.08: Domain d5xy1a1: 5xy1 A:239-502

Lineage for d5xy1a1 (5xy1 A:239-502)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d5xy1a1: 5xy1 A:239-502 [337378]
   Other proteins in same PDB: d5xy1a2
   automated match to d2bdfb_
   complexed with 8h0

Details for d5xy1a1

PDB Entry: 5xy1, 2.7 Å

PDB Description: crystal structure of lyn kinase domain in complex with n-(1h-indazol- 6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine

PDB Compounds: (A:) tyrosine-protein kinase lyn

SCOPe Domain Sequences for d5xy1a1:

Sequence, based on SEQRES records:

>d5xy1a1 d.144.1.7 (A:239-502) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aweipresiklvkrlgagqfgevwmgyynnstkvavktlkpgtmsvqafleeanlmktlq
hdklvrlyavvtreepiyiiteymakgslldflksdeggkvllpklidfsaqiaegmayi
erknyihrdlraanvlvseslmckiadfglarviedneytaregakfpikwtapeainfg
cftiksdvwsfgillyeivtygkipypgrtnadvmtalsqgyrmprvencpdelydimkm
cwkekaeerptfdylqsvlddfyt

Sequence, based on observed residues (ATOM records):

>d5xy1a1 d.144.1.7 (A:239-502) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aweipresiklvkrlgagqfgevwmgyynnstkvavktlkpgtmsvqafleeanlmktlq
hdklvrlyavvtreepiyiiteymakgslldflksdeggkvllpklidfsaqiaegmayi
erknyihrdlraanvlvseslmckiadfglarvkfpikwtapeainfgcftiksdvwsfg
illyeivtygkipypgrtnadvmtalsqgyrmprvencpdelydimkmcwkekaeerptf
dylqsvlddfyt

Timeline for d5xy1a1:

• d5xy1a1 first appeared in SCOPe 2.06
  
• d5xy1a1 appears in SCOPe 2.07