SCOPe 2.08: Domain d5kvub_: 5kvu B:

Lineage for d5kvub_ (5kvu B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 proteins)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
   automatically mapped to Pfam PF03971

6. Protein automated matches [190493] (6 species)
   not a true protein

7. Species Mycobacterium tuberculosis [TaxId:83332] [336802] (1 PDB entry)

8. Domain d5kvub_: 5kvu B: [336914]
   automated match to d2b0ta_
   complexed with edo, gol, mla, mlt, nap, sin

Details for d5kvub_

PDB Entry: 5kvu, 2.66 Å

PDB Description: crystal structure of isocitrate dehydrogenase-2 in complex with nadp(+) from mycobacterium tuberculosis

PDB Compounds: (B:) isocitrate dehydrogenase

SCOPe Domain Sequences for d5kvub_:

Sequence; same for both SEQRES and ATOM records:

>d5kvub_ c.77.1.2 (B:) automated matches {Mycobacterium tuberculosis [TaxId: 83332]}
ptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylteeqrvp
dnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdqekaik
eryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrhgdfya
geksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyeeqmqda
fetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnnglsdlysk
ieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamiraggkm
ygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqaeeygsh
dktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtrarisgm
pvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgldtiaat
gnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveenhlrwd
slgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnrgsqfy
lamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyyapdsdm
ttavmrpsktfnaaleav

Timeline for d5kvub_:

• d5kvub_ first appeared in SCOPe 2.06
  
• d5kvub_ appears in SCOPe 2.07