SCOPe 2.08: Domain d5x4xa_: 5x4x A:

Lineage for d5x4xa_ (5x4x A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)

8. Domain d5x4xa_: 5x4x A: [336417]
   automated match to d4eb4a_
   complexed with so4; mutant

Details for d5x4xa_

PDB Entry: 5x4x, 2.31 Å

PDB Description: mutant human thymidylate synthase a191k crystallized in a sulfate- containing condition

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d5x4xa_:

Sequence, based on SEQRES records:

>d5x4xa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
hgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmklppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem

Sequence, based on observed residues (ATOM records):

>d5x4xa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
hgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgq
gvdqlqrvidtiktnpddrriimcawnprdlplmklppchalcqfyvvnselscqlyqrs
gdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpf
pklrilrkvekiddfkaedfqiegynphptikmem

Timeline for d5x4xa_:

• d5x4xa_ first appeared in SCOPe 2.06
  
• d5x4xa_ appears in SCOPe 2.07