SCOPe 2.08: Domain d5x69e_: 5x69 E:

Lineage for d5x69e_ (5x69 E:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)

8. Domain d5x69e_: 5x69 E: [336398]
   automated match to d2aaza_
   complexed with 7zc, ump

Details for d5x69e_

PDB Entry: 5x69, 2.69 Å

PDB Description: human thymidylate synthase with a fragment bound in the dimer interface

PDB Compounds: (E:) Thymidylate synthase

SCOPe Domain Sequences for d5x69e_:

Sequence, based on SEQRES records:

>d5x69e_ d.117.1.1 (E:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

Sequence, based on observed residues (ATOM records):

>d5x69e_ d.117.1.1 (E:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkdgtlsvfgmqaryslrdefpllttkrvfwkgvleellw
fikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdme
sdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselsc
qlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlq
reprpfpklrilrkvekiddfkaedfqiegynphpt

Timeline for d5x69e_:

• d5x69e_ first appeared in SCOPe 2.06
  
• d5x69e_ appears in SCOPe 2.07