SCOPe 2.06: Domain d5jm5b_: 5jm5 B:

Lineage for d5jm5b_ (5jm5 B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (43 PDB entries)
   Uniprot P42330

8. Domain d5jm5b_: 5jm5 B: [333761]
   automated match to d2fgba_
   complexed with 6lg, 6ny, nap

Details for d5jm5b_

PDB Entry: 5jm5, 1.99 Å

PDB Description: crystal structure of akr1c3 complexed with a pro-drug

PDB Compounds: (B:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d5jm5b_:

Sequence, based on SEQRES records:

>d5jm5b_ c.1.7.1 (B:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
kqqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvgl
airskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslk
pgeelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglk
ykpvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlca
lakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnl
hyfnsdsfashpnypy

Sequence, based on observed residues (ATOM records):

>d5jm5b_ c.1.7.1 (B:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
kqqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvgl
airskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslk
pgeelsptkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpv
cnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakk
hkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfn
sdsfashpnypy

Timeline for d5jm5b_:

• d5jm5b_ is new in SCOPe 2.06-stable
  
• d5jm5b_ appears in SCOPe 2.07
  
• d5jm5b_ appears in the current release, SCOPe 2.08, called d5jm5b1