SCOPe 2.08: Domain d5hzea_: 5hze A:

Lineage for d5hzea_ (5hze A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
   Uniprot Q02750 61-381

8. Domain d5hzea_: 5hze A: [333719]
   automated match to d5bx0a_
   complexed with e62, mg

Details for d5hzea_

PDB Entry: 5hze, 2.4 Å

PDB Description: mek1 adopts dfg-out conformation when bound to an analog of e6201.

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d5hzea_:

Sequence, based on SEQRES records:

>d5hzea_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmans
fvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegd
aaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcl
iknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d5hzea_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgt
rsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyi
vnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcs
tigln

Timeline for d5hzea_:

• d5hzea_ first appeared in SCOPe 2.06
  
• d5hzea_ appears in SCOPe 2.07