SCOPe 2.08: Domain d5mqve_: 5mqv E:

Lineage for d5mqve_ (5mqv E:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)

8. Domain d5mqve_: 5mqv E: [332780]
   automated match to d1ckia_
   complexed with d5q, po4

Details for d5mqve_

PDB Entry: 5mqv, 2.15 Å

PDB Description: crystal structure of human casein kinase i delta in complex with 4-(2, 5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h- imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide

PDB Compounds: (E:) Casein kinase I isoform delta

SCOPe Domain Sequences for d5mqve_:

Sequence; same for both SEQRES and ATOM records:

>d5mqve_ d.144.1.7 (E:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
ryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgipt
irwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihr
dvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlg
ieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypse
fatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk

Timeline for d5mqve_:

• d5mqve_ first appeared in SCOPe 2.06
  
• d5mqve_ appears in SCOPe 2.07