SCOPe 2.08: Domain d5mwja1: 5mwj A:443-770

Lineage for d5mwja1 (5mwj A:443-770)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (15 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.4: WD40 repeat-like [50978] (4 families)
   also contains 8-bladed propellers

5. Family b.69.4.1: WD40-repeat [50979] (17 proteins)
   this is a repeat family; one repeat unit is 1tyq C:201-243 found in domain

6. Protein Groucho/tle1, C-terminal domain [75009] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [75010] (4 PDB entries)

8. Domain d5mwja1: 5mwj A:443-770 [332688]
   Other proteins in same PDB: d5mwja2, d5mwjb2
   automated match to d1gxra_
   complexed with dms, ebu
   has additional insertions and/or extensions that are not grouped together

Details for d5mwja1

PDB Entry: 5mwj, 2.04 Å

PDB Description: structure enabled discovery of a stapled peptide inhibitor to target the oncogenic transcriptional repressor tle1

PDB Compounds: (A:) transducin-like enhancer protein 1

SCOPe Domain Sequences for d5mwja1:

Sequence, based on SEQRES records:

>d5mwja1 b.69.4.1 (A:443-770) Groucho/tle1, C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
kpaysfhvtadgqmqpvpfppdaligpgiprharqintlnhgevvcavtisnptrhvytg
gkgcvkvwdishpgnkspvsqldclnrdnyirsckllpdgctlivggeastlsiwdlaap
tprikaeltssapacyalaispdskvcfsccsdgniavwdlhnqtlvrqfqghtdgasci
disndgtklwtggldntvrswdlregrqlqqhdftsqifslgycptgewlavgmessnve
vlhvnkpdkyqlhlhescvlslkfaycgkwfvstgkdnllnawrtpygasifqskesssv
lscdisvddkyivtgsgdkkatvyeviy

Sequence, based on observed residues (ATOM records):

>d5mwja1 b.69.4.1 (A:443-770) Groucho/tle1, C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
kpaysfhvtqmqpvpfppdaligpgiprharqintlnhgevvcavtisnptrhvytggkg
cvkvwdisspvsqldclnrdnyirsckllpdgctlivggeastlsiwdlprikaeltssa
pacyalaispdskvcfsccsdgniavwdlhnqtlvrqfqghtdgascidisndgtklwtg
gldntvrswdlregrqlqqhdftsqifslgycptgewlavgmessnvevlhvnkpdkyql
hlhescvlslkfaycgkwfvstgkdnllnawrtpygasifqskesssvlscdisvddkyi
vtgsgdkkatvyeviy

Timeline for d5mwja1:

• d5mwja1 first appeared in SCOPe 2.06
  
• d5mwja1 appears in SCOPe 2.07