SCOPe 2.07: Domain d5mo4a3: 5mo4 A:241-531

Lineage for d5mo4a3 (5mo4 A:241-531)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (835 PDB entries)

8. Domain d5mo4a3: 5mo4 A:241-531 [332641]
   Other proteins in same PDB: d5mo4a1, d5mo4a2
   automated match to d1opka3
   complexed with ay7, nil

Details for d5mo4a3

PDB Entry: 5mo4, 2.17 Å

PDB Description: abl1 kinase (t334i_d382n) in complex with asciminib and nilotinib

PDB Compounds: (A:) Tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d5mo4a3:

Sequence, based on SEQRES records:

>d5mo4a3 d.144.1.7 (A:241-531) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kptvygvspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeve
eflkeaavmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvll
ymatqissameylekknfihrnlaarnclvgenhlvkvadfglsrlmtgdtytahagakf
pikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerp
egcpekvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk

Sequence, based on observed residues (ATOM records):

>d5mo4a3 d.144.1.7 (A:241-531) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kptvygvspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedeveef
lkeaavmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllym
atqissameylekknfihrnlaarnclvgenhlvkvadffpikwtapeslaynkfsiksd
vwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnps
drpsfaeihqafetmfqessisdevekelgk

Timeline for d5mo4a3:

• d5mo4a3 first appeared in SCOPe 2.06