SCOPe 2.08: Domain d5mw4a_: 5mw4 A:

Lineage for d5mw4a_ (5mw4 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein automated matches [191247] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189737] (31 PDB entries)

8. Domain d5mw4a_: 5mw4 A: [331721]
   automated match to d4hraa_
   complexed with 5ju, so4

Details for d5mw4a_

PDB Entry: 5mw4, 2.19 Å

PDB Description: crystal structure of dot1l in complex with inhibitor cpd7 [n-(3-(((r)- 1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino) propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5- yl)ureido)acetamide]

PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d5mw4a_:

Sequence, based on SEQRES records:

>d5mw4a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslkn

Sequence, based on observed residues (ATOM records):

>d5mw4a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgntrpstgllrhilqqvynhsvtdpekgetsfdl
vaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipakyaetmdrefr
kwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhqlkerfanmkeg
grivsskpfaplnfrinsrnlsdigtimrvvelsplkswtgkpvsyylhtidrtilenyf
sslkn

Timeline for d5mw4a_:

• d5mw4a_ first appeared in SCOPe 2.06
  
• d5mw4a_ appears in SCOPe 2.07