SCOPe 2.08: Domain d5mw3a_: 5mw3 A:

Lineage for d5mw3a_ (5mw3 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein automated matches [191247] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189737] (31 PDB entries)

8. Domain d5mw3a_: 5mw3 A: [331719]
   automated match to d4hraa_
   complexed with 5jj, 5jt, tla

Details for d5mw3a_

PDB Entry: 5mw3, 2.09 Å

PDB Description: crystal structure of dot1l in complex with inhibitor cpd1 [n6-(2,6- dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6-diamine] and inhibitor cpd2 [(r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3- amine]

PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d5mw3a_:

Sequence, based on SEQRES records:

>d5mw3a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslknp

Sequence, based on observed residues (ATOM records):

>d5mw3a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgtntrpstgllrhilqqvynhsvtdpeklnnyep
fspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadi
pakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevd
hqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkswtgkpvsyy
lhtidrtilenyfsslknp

Timeline for d5mw3a_:

• d5mw3a_ first appeared in SCOPe 2.06
  
• d5mw3a_ appears in SCOPe 2.07