SCOPe 2.06: Domain d5l4nc_: 5l4n C:

Lineage for d5l4nc_ (5l4n C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Leishmania major [TaxId:5664] [63926] (13 PDB entries)
   Uniprot Q01782

8. Domain d5l4nc_: 5l4n C: [331681]
   automated match to d1e92b_
   complexed with 6qt, act, edo, gol, ndp, peg, pge

Details for d5l4nc_

PDB Entry: 5l4n, 2.35 Å

PDB Description: leishmania major pteridine reductase 1 (ptr1) in complex with compound 1

PDB Compounds: (C:) pteridine reductase 1

SCOPe Domain Sequences for d5l4nc_:

Sequence, based on SEQRES records:

>d5l4nc_ c.2.1.2 (C:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d5l4nc_ c.2.1.2 (C:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadl
fgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleg
ltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvvif
lcsskakyitgtcvkvdggysltra

Timeline for d5l4nc_:

• d5l4nc_ is new in SCOPe 2.06-stable
  
• d5l4nc_ appears in SCOPe 2.07
  
• d5l4nc_ appears in the current release, SCOPe 2.08