SCOPe 2.08: Domain d5tzzd_: 5tzz D:

Lineage for d5tzzd_ (5tzz D:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (9 families)

5. Family a.211.1.0: automated matches [191566] (1 protein)
   not a true family

6. Protein automated matches [190983] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188676] (139 PDB entries)

8. Domain d5tzzd_: 5tzz D: [330130]
   Other proteins in same PDB: d5tzza2, d5tzzb2
   automated match to d4d09a_
   complexed with 7oj, mg, zn

Details for d5tzzd_

PDB Entry: 5tzz, 1.6 Å

PDB Description: crystal structure of human phosphodiesterase 2a in complex with 1-[(3- bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}piperidine

PDB Compounds: (D:) cGMP-dependent 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d5tzzd_:

Sequence, based on SEQRES records:

>d5tzzd_ a.211.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlar
fclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhr
gtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlm
rdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrk
iaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpka
aelyervasnrehwtkvshkftirglpsnnsldfld

Sequence, based on observed residues (ATOM records):

>d5tzzd_ a.211.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ytkliqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclm
vkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnn
sfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdii
latdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiael
iykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaely
ervasnrehwtkvshkftirglpsnnsldfld

Timeline for d5tzzd_:

• d5tzzd_ first appeared in SCOPe 2.06
  
• d5tzzd_ appears in SCOPe 2.07