SCOPe 2.07: Domain d5tn9a_: 5tn9 A:

Lineage for d5tn9a_ (5tn9 A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (82 PDB entries)
   Uniprot P03372 307-551

8. Domain d5tn9a_: 5tn9 A: [329854]
   automated match to d3q95b_
   complexed with 7ec

Details for d5tn9a_

PDB Entry: 5tn9, 2.25 Å

PDB Description: crystal structure of the er-alpha ligand-binding domain (l372s,l536s) in complex with the obhs-bsc, 4-bromophenyl (1r,2r,4s)-5-(4- hydroxyphenyl)-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-7- oxabicyclo[2.2.1]hept-5-ene-2-sulfonate

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d5tn9a_:

Sequence, based on SEQRES records:

>d5tn9a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
a

Sequence, based on observed residues (ATOM records):

>d5tn9a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnmveifdmllats
srfrmmnlqgeefvclksiillnsgvytfsleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehknvvpsydlllemlda

Timeline for d5tn9a_:

• d5tn9a_ first appeared in SCOPe 2.06
  
• d5tn9a_ appears in the current release, SCOPe 2.08