SCOPe 2.07: Domain d5svoa_: 5svo A:

Lineage for d5svoa_ (5svo A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (22 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189131] (10 PDB entries)

8. Domain d5svoa_: 5svo A: [329523]
   automated match to d1lwda_
   complexed with epe, nap; mutant

Details for d5svoa_

PDB Entry: 5svo, 1.87 Å

PDB Description: structure of idh2 mutant r140q

PDB Compounds: (A:) Isocitrate dehydrogenase [NADP], mitochondrial

SCOPe Domain Sequences for d5svoa_:

Sequence; same for both SEQRES and ATOM records:

>d5svoa_ c.77.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
krikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtidsa
latqkysvavkcatitpdearveefklkkmwkspngtiqnilggtvfrepiickniprlv
pgwtkpitigrhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgmgm
yntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfdkn
kiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdgkt
ieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmlekv
cvetvesgamtkdlagcihglsnvklnehflnttdfldtiksnldralgr

Timeline for d5svoa_:

• d5svoa_ first appeared in SCOPe 2.06
  
• d5svoa_ appears in the current release, SCOPe 2.08